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Night shifts not linked to breast cancer risk, new study finds

Working night shifts does not increase the risk of breast cancer in women, according to new research part-funded by the UK Health and Safety Executive (HSE).

Night shifts not linked to breast cancer risk, new study finds
Image credit: ©iStock/Tashi-Delek

The study, published in the Journal of the National Cancer Institute, questioned 522,246 Million Women Study, 22,559 EPIC-Oxford, and 251,045 UK Biobank participants on shift work and then followed them for incident cancer. The results were combined with data from seven previously published studies (covering 1.4 million women in total) from the US, China, Sweden and the Netherlands.

Researchers found that women who had worked night shifts (including those who had done so for up to 30 years) had no increased risk of breast cancer compared with women who had never worked shifts. 

In the Million Women Study, EPIC-Oxford, and UK Biobank respectively, 673, 28 and 67 women who reported night shift work developed breast cancer. The combined relative risks taking all ten studies together were 0.99 for any night shift work, 1.01 for 20 or more years of night shift work, and 1.00 for 30 or more years night shift work. 

The findings contradict a 2007 review by the International Agency for Research on Cancer that said shift work disrupted the “body clock” and was a probable cause of cancer. This was mainly based on animal and lab studies. 

The latest work builds on a Canadian study of 1,134 breast cancer sufferers and 1,179 women of similar ages without the disease which found the risk factor was apparent only in those working nights for more than half a normal working life. 

Dr Ruth Travis, lead author and a Cancer Research UK-funded scientist at the Cancer Epidemiology Unit at the University of Oxford, said: “We found that women who had worked night shifts, including long-term night shifts, were not more likely to develop breast cancer, either in the three new UK studies or when we combined results from all ten studies that had published relevant data.” 

The research, Night Shift Work and Breast Cancer Incidence: Three Prospective Studies and Meta-analysis of Published Studies, was funded by the HSE, Cancer Research UK and the UK Medical Research Council. 

Sarah Williams, Cancer Research UK’s health information manager, said: “This study is the largest of its kind and has found no link between breast cancer and working night shifts. We hope [this] news reassures women who work night shifts.” 

Professor Andrew Curran, chief scientific adviser for the HSE, which commissioned the study, added: “This study has shown that night shift work, including long-term shift work, has little or no effect on breast cancer incidence in women. However, there are a number of other known risks with shift work that employers must take into consideration when protecting their workers’ health and safety.” 

On average, one in seven (14%) women in the UK have ever worked nights and one in 50 (2%) have worked nights for 20 or more years. Each year in the UK around 53,300 women are diagnosed with breast cancer and around 11,500 die from the disease.


Keeley Downey was the former assistant editor of IOSH Magazine. Previously she was editor of Biofuels International, Bioenergy Insight and Tank Cleaning Magazine

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  • I suspect in a few years time

    Permalink Submitted by Steven Nagle on 12 October 2016 - 01:30 pm

    I suspect in a few years time there will be another survey saying this one was wrong. We all know night working has a number of effects on the body, and until much more detailed studies on a medical level are done (intrusively), I suspect it is probably very difficult to say whether a link exists or not, and if we apply best practice, assume it does have such a potential effect. That said, everything else apparently causes cancer these days, so why not Night Shifts?

  • Looking at the journal the

    Permalink Submitted by Leo van der Biessen on 14 October 2016 - 08:53 am

    Looking at the journal the study is published in, I think the study should be assessed as reliable. Because the Oxfords Journals describes the journal as followed: "The Journal of the National Cancer Institute (print ISSN: 0027-8874, online ISSN: 1460-2105) publishes peer-reviewed original research from around the world and is internationally acclaimed as the source for the most up-to-date news and information from the rapidly changing fields of cancer research and treatment. For the past several years, the JNCI has been ranked as one of the most-cited original-research cancer journals by the Institute of Scientific Information in its annual Journal Citation Reports."
    The idea that whenever a potential hazard is present, we should assume the worst and then take steps to eliminate that hazard is simply wrong. It will lead to nothing but a waste of time and effort. This time and effort can then not be spent on more plausible / more significant hazards because in the real world we do not have infinite resources. Data from properly devised epidemiological studies have greater value than animal testing. The fact that lots of things are being said to cause cancer stems from our increased knowledge on the subject and improvements in hygiene and medicine.


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